Document Type : Original Research Article


Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India


The newly synthesized 3-(phenyl(phenylthio)methyl)-1H-indole ligand demonstrates chemosensor activity towards environmental and clinically important metal ions viz. Hg2+ and Cu2+, via fluorescence intensity enhancement. The rigid complex ceases non-radiative channels with respect to the free ligand. Incorporation of water and significant fluorescence enhancement in presence of interfering metal ions make the method superior over others and detect trace amount of metal ions into the aqueous based medium. Also, the detection of Hg2+ and Cu2+ ions are considered as subjects of an increasing societal demand as well as responsible for neurodegenerative disorders.

Graphical Abstract

Indole derived “turn-on” fluorometric probe for dual detection of Hg2+ and Cu2+ ions at nanomolar level


Main Subjects

[1]. Devi C.L., Thurakkal S., Shankar B.H., Ramaiah D. Sensors Actuators B Chem., 2014, 204:480

[2]. He X., Zhang J., Liu X., Dong L., Li D., Qiu H., Yin S. Sensors Actuators B Chem., 2014, 192:29

[3]. Kaur M., Choi D.H. Sensors Actuators B Chem., 2014, 190:542

[4]. Wang X., Zhao J., Guo C., Pei M., Zhang G. Sensors Actuators B Chem., 2014, 193:157

[5]. Martínez R., Espinosa A., Tárraga A., Molina P. Org. Lett., 2005, 7:5869

[6]. Kim S.H., Kim J.S., Park S.M., Chang S.K. Org. Lett., 2006, 8:371

[7]. Hutchinson T.C., Meema K.M. Lead, Mercury, Cadmium and Arsenic in the Environment; scope 31, John Wiley & Sons, Chichester, 1987, 384

[8]. Dalapati S., Paul B.K., Jana S., Guchhait N. Sensors Actuators B Chem., 2011, 157:615

[9]. Fitzgerald W.F., Lamborg C.H., Hammerschmidt C.R. Chem. Rev., 2007, 107:641

[10]. Que E.L., Domaille D.W., Chang C.J. Chem. Rev., 2008, 108:1517

[11]. Andreini C., Banci L., Bertini I., Rosato A. J. Proteome Res., 2008, 7:209

[12]. Karlsson H.L., Cronholm P., Gustafsson J., Möller L. Chem. Res. Toxicol., 2008, 21:1726

[13]. Barceloux D.G. Clin. Toxicol., 1999, 37:217

[14]. Uauy R., Olivares M., Gonzalez M. Am. J. Clin. Nutr., 1998, 67:952S

[15]. Strausak D., Mercer J.F.B., Dieter H.H., Stremmel W., Multhaup G. Brain Res. Bull., 2001, 55:175

[16]. Wegner S.V., Arslan H., Sunbul M., Yin J., He C. J. Am. Chem. Soc., 2010, 132:2567

[17]. Ye H., Ge F., Chen X.C., Li Y., Zhang H., Zhao B.X., Miao J.Y. Sensors Actuators B Chem., 2013, 182:273

[18]. Wang M., Yan F., Zou Y., Chen L., Yang N., Zhou X. Sensors Actuators B Chem., 2014, 192:512

[19]. Yang Y., Gao C., Li B., Xu L., Duan L. Sensors Actuators B Chem., 2014, 199:121

[20]. Hatai J., Pal S., Jose G.P., Bandyopadhyay S. Inorg. Chem., 2012, 51:10129

[21]. Hussain S., De S., Iyer P.K. ACS Appl. Mater. Interfaces, 2013, 5:2234

[22]. Saikia G., Dwivedi A.K., Iyer P.K. Anal. Methods., 2012, 4:3180

[23]. Mahapatra A.K., Hazra G., Das N.K., Goswami S. Sensors Actuators B Chem., 2011, 156:456

[24]. Chandrasekhar V., Pandey M.D. Tetrahedron Lett., 2011, 52:1938

[25]. Chen Y., Zhu C., Yang Z., Li J., Jiao Y., He W., Chen J., Guo Z. Chem. Commun., 2012, 48:5094

[26]. Bose P., Ghosh P. Chem. Commun., 2010, 46:2962

[27]. Dar A.A., Ali S., Ghosh A., Khan A.T., Dwivedi A.K., Iyer P.K. Sensors Actuators B Chem., 2014, 193:509

[28]. Dar A.A., Ali S., Khan A.T. Tetrahedron Lett., 2014, 55:486

[29]. Kaur P., Kaur S., Singh K. Org. Biomol. Chem., 2012, 10:1497

[30]. Kaur P., Kaur S., Singh K., Sharma P.R., Kaur T. Dalt. Trans., 2011, 40:10818

[31]. Rathikrishnan K.R., Indirapriyadharshini V.K., Ramakrishna S., Murugan R. Tetrahedron, 2011, 67:4025

[32]. Wang L., He X., Guo Y., Xu J., Shao S. Org. Biomol. Chem., 2011, 9:752