Document Type : Original Research Article

Authors

Department of Chemistry, Gauhati University, Guwahati -781014, India

Abstract

A mixture of two ionic liquids have been used for a green synthesis of 3,4,6-triarylpyridazine in high yield and at room temperature. The two ionic liquids acts in tandem. The advantage of this method is a room temperature synthesis of the target compounds using green methodology.  Product recovery is simple and the mixture of ionic liquids can be recovered and recycled.

Graphical Abstract

Synergy of binary ionic liquids in a three component one-pot synthesis of 3,4,6-triarylpyridazine at ambient temperature

Keywords

Main Subjects

[1]. Rohet F., Rubat C., Coudert P., Couquelet J. Bioorg. Med. Chem.,1997, 5:655

[2]. Numata T., Obato T., Hirat K., Kudo M. Jpn. Kokai Tokyo Koho Jp.,1989, 63:159

[3]. Yoshioka H., Obato T., Fujii K., Fukud Y., Ooka A. Eur. Pat. Appl. Ep., 1989, 283:271

[4]. Matolesy G. World Rev. Pev. Pest Contr., 1971, 10:50

[5]. Okujima H., Naeimatsu A., Kobayashi M., Funlya R., Kitada K.  Jpn. Kokai Tokyo Jp., 1989, 63:215

[6]. Preshin G.N., Sherbakova L.I., Zykova T.N., Sokolova V.N. Farmakol. Toksikol., 1971, 35:466

[7]. Helm M.D., Moore J.E., Plant A., Harrity J.P.A. Angew. Chem., Int. Ed., 2005, 44:3889

[8]. Bel Abed H., Mammoliti O., Bande O., Lommen G.V.,  Herdewijn P., J. Org. Chem., 2013, 78:7845

[9]. Mao H., Lin A., Tang Z., Hu H., Zhu Ch., Cheng Y. Chemistry- an European Journal, 2004, 20:2454

[10]. Donohoe T.J., Fishlock L.P., Basutto J.A., Bower J.F., Procopiou P.A., Thompson A.L. Chem. Commun. 2009, 3008 http://dx.doi.org/10.1039/B904363B

[11]. Sotelo E., Coelho A., Ravina E. Tetrahedron lett., 2003, 44:4459

[12]. Gao Q., Zhu Y., Lian M., Liu M., Yuan J., Yin G., Wu A. J.Org. Chem., 2012, 77:9865

[13]. Kessler S.N., Wegner H.A., Org. Lett., 2012, 14:3268

[14]. Elnadi M.H., Al Awadi N.A., Abdelhamid I.A.  Advances in Heterocyclic Chemistry, 2009, 97:1

[15]. Ball C.J., Gilmore J., Willis, M.C. Agnew. Chem. Int. Ed., 2012, 51:5718

[16]. Borisov A.V., Voloshchuk V.V., Nechayev M.A., Grygorenko O.O. Synthesis, 2013, 45:2413

[17]. Dupont J., de Souza R.F., Suarez P.A.Z. Chem. Rev., 2002, 102:3667

[18]. Wilkes J.S. Green Chem., 2002, 4:73

[19]. Wasserscheid P., Keim W. Agnew. Chem. Int Ed., 2002, 39:3772

[20]. Sheldon R.A. Green Chem., 2005, 7:267

[21]. Sheldon R. Chem. Commun., 2001, 2399 http://dx.doi.org/10.1039/B107270F

[22]. Bigi F., Magi R., Sartori G. Green Chem., 2000, 2:140

[23]. Earle M.J., Seddon K.R., Pure Appl. Chem., 2000, 72:1391

[24]. Verma R.S, Namboodri V.V. Pure Appl. Chem., 2001, 73:1309

[25]. Ghandi K. Green and sustainable Chemistry, 2014, 4:44

[26]. Zin T.S., Zhang J.S., Qwang A., Li T.S. Chemistry-an Indian Journal, 2004, 1:253

[27]. Mecadon H., Myrboh B. ISRN Org. Chem., 2011, 1:2011

[28]. Nongkhlaw R.L., Nongrum R., Myrbuh B.  Heterocyclic Commun., 2003, 9:165