CiteScore: 1.9     h-index: 21

Document Type : Original Research Article


Department of Chemistry, Payam Noor University, Birjand, Iran


ZnFe2O4 as a novel nanoparticle was prepared and characterized using x-ray diffraction (XRD) analysis, energy dispersive x-ray (EDX), vibrating sample magnetometry (VSM), and fourier-transform infrared (FTIR) spectra. Then, it is used one-pot three-components synthesis of spirooxindole derivatives via condensation of isatin, malononitrile, and 1,3-dicarbonyl compounds (1,3-cyclohexanedione) under mild reaction conditions in water as a green solvent. The present methodology offers several advantages, including ease of the preparation and handling of the catalyst, simple and easy work-up, short reaction times, high yields of the products and recyclability of the catalyst.          

Graphical Abstract

One-pot synthesis of spirooxindole derivatives catalyzed by ZnFe2O4 as a magnetic nanoparticles


Main Subjects

[1]. Hajinasiri R., Rezayat S. Z. Naturforsch, 2013, 68b:818
[2]. Tietze L.F., Modi A. Med. Res. Rev., 2000, 20:304
[3]. Simon C., Constantieux T., Rodriguez J. Eur. J. Org. Chem., 2004, 25:4957
[4]. Ramon D.J., Yus M. Angew. Chem., Int. Ed., 2005, 44:1602
[5]. Bienayme H., Hulme C., Oddon G., Schmitt P. Chem. Eur. J. 2000, 6:3321
[6]. Nair V., Vinod A.U., Rajesh C. J. Org. Chem., 2001, 66:4427
[7]. List B., Castello C. Synlett, 2001, 1687
[8]. Bertozzi F., Gustafsson M., Olsson R. Org. Lett., 2002, 4:3147
[9]. Cheng J.F., Chen M., Arthenius T., Nadzen A. Tetrahedron Lett., 2002, 43:6293
[10]. Houlihan W.J., Remers W.A., Brown R.K. Indoles: Part I; Wiley: New York, 1992.
[11]. Sundberg R.J., The Chemistry of Indoles; Academic: New York, 1996.
[12]. Da-Silva J.F.M., Garden S.J., Pinto A.C. J. Braz. Chem. Soc., 2001, 12:273
[13]. Abdel Rahman A.H., Keshk E.M., Hanna M.A., El-Bady S.M. Bioorg. Med. Chem., 2004, 12:2483
[14]. Sebahar P.R., Williams R.M. J. Am. Chem. Soc., 2000, 122:5666
[15]. Ma J., Hecht S.M. Chem. Commun., 2004, 17:1190
[16]. Edmondson S., Danishefsky S.J., Sepp-Lorenzinol L., Rosen N. J. Am. Chem. Soc., 1999, 121:2147
[17]. Breslow R., Bovy P., Hersh C.L. J. Am. Chem. Soc., 1980, 102:2115
[18]. Shi D.Q., Mou J., Zhuang Q.Y., Niu L.H., Wu N., Wang X.S. Synth. Commun., 2004, 34:4557
[19]. Wang D., He J., Rosenzweig N., Rosenzweig Z., Nano Lett., 2004, 4:409
[20]. Jordan A., Scholz R., Wust P., Fahling H., Felix R., J. Magn. Magn. Mater., 1999, 201:413
[21]. Pankhurst Q.A., Connolly J., Jones S.K., Dob-Son J. J. Phys. D Appl. Phys., 2003, 36:167
[22]. Gupta A.K., Curtis A.S.G. J. Mater. Sci. Mater. Med., 2004, 15:493
[23]. Hyeon T. Chem. Commun., 2003, 927. doi:10.1039/B207789B
[24]. Lu A., Schmidt W., Matoussevitch N., Bonnemann H., Spliethoff B., Tesche B., Bill E., Kiefer W., Schuth F. Angew. Chem., 2004, 116:4403
[25]. Perez J.M., Simeone F.J., Saeki Y., Josephson L., Weissleder R., J. Am. Chem. Soc., 2003, 125:10192
[26]. Jia Z.G., Ren D.P., Liang Y.C., Zhu R.S. Mater. Lett., 2011, 65:3116
[27]. Dong H., Li X.L., Peng Q., Wang X., Chen J.P., Li Y.D. Angew. Chem., Int. Ed., 2005, 44:2782
[28]. Wang M., Ai Z.H., Zhang L.Z. J. Phys. Chem. C., 2008, 112:13163
[29]. Su L., Feng J., Zhou Z., Ren C., Li H., Chen X. Anal. Chem., 2012, 84:5753
[30]. Habibi M.H., Habibi A.H., Zendehdel M., Habibi M. Spectrochim. Acta, Part A. 2013, 110:226
[31]. Guo P., Cui L., Wang Y., Lv M., Wang B., Zhao X.S. Langmuir, 2013, 29:8997