Solvent-free mechanochemical green synthesis of Schiff bases of tranexamic acid and study of their urease inhibitory and antioxidant activities

Zulfiqar, Abid; Ahmed, Dildar

doi:10.22034/ajgc.2022.1.4

Document Type : Original Research Article

Authors

Abid Zulfiqar ¹^{, 2}
Dildar Ahmed ¹

¹ Department of Chemistry, Forman Christian College Lahore, Pakistan

² Present affiliation: INM-Leibniz Institute for New Materials, Campus D2-2, 66123 Saarbruecken, Germany

https://doi.org/10.22034/ajgc.2022.1.4

Abstract

Three Schiff bases of tranexamic acid were successfully synthesized by a mechanochemical green method, which is 4-{(5-bromo-2- hydroxybenzylidene)amino]methyl}cyclohexanecarboxylic acid (SB1), 4-{(2-hydroxybenzylidene)amino]methyl}cyclohexanecarboxylic acid (SB2), and 4-{(4-nitrobenzylidene)amino]methyl}cyclohexanecarboxylic acid (SB3) in good yield. Their structures were confirmed based on spectroscopic data. The bases displayed considerable urease inhibitory activity with IC₅₀ (µg/mL) 33.41, 40.64, 26.18, and 11.14 for SB1, SB2, SB3, and standard thiourea, respectively. They revealed weak antiradical activity in DPPH assay with EC₅₀ (µg/mL) 1138, 1239, and 24248 for SB1, SB2, and SB3, respectively. In conclusion, grinding is an efficient and environmentally friendly method for synthesizing these bases, which may provide potential candidates for new medicines.

Graphical Abstract

Keywords

Main Subjects

Organic Chemistry

References

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Asian Journal of Green Chemistry

Solvent-free mechanochemical green synthesis of Schiff bases of tranexamic acid and study of their urease inhibitory and antioxidant activities

References

References

Volume 6, Issue 1
January 2022
Pages 40-47

Solvent-free mechanochemical green synthesis of Schiff bases of tranexamic acid and study of their urease inhibitory and antioxidant activities

References

References

Volume 6, Issue 1January 2022Pages 40-47

Volume 6, Issue 1
January 2022
Pages 40-47