CiteScore: 1.8     h-index: 21

Document Type : Original Research Article

Authors

Department of chemistry, College of Science, University of Baghdad, Jadiriya, Baghdad, Iraq

Abstract

In this research study we synthesized new tetrazoline from a reaction of 2-N-arylidene amino creatinine with sodium azide and 2-N-azido acetamido creatinine. The prepared compound was characterized using the FT-IR, and 1H NMR. All the physical properties and studied biological activity of synthesized compounds. The compounds 8b and 13c were given more active against gram positive, gram negative bacteria and fungi.

Graphical Abstract

Synthesis of derivatives of tetrazoline on Creatinine and study their biological activity

Keywords

Main Subjects

[1]. Anu K., Suman B., Sunil K., Neha Sh., Vipin S., Journal of Catalysts, 2013, 13:1 
[2]. Anita R., Manoj K., Rajshree K., Hardeep S.T. Journal of Biological and Chemical Sciences, 2015, 2:62
[3]. Hussein I.A., Narren S.F., Hasan I.M.M., Saleh A.M. J. Pharm. Sci. Res. 2018, 10:2461
[4]. Fahmi H., Zachary P.D., Louis N., Sharpless K.B. J. American. Chem. Soc., 2003, 125:9983
[5]. Avaji P.G., Kumar C.H.V., Patil S.A. Eur. J. Med. Chem., 2009, 44:3552
[6]. Zang Y., Zang L., Liu L. Chim. Acta., 2010, 363:289
[7]. Lima L.M., Frattani F.S., Dos Santos J.L. Eur. J. Med. Chem., 43:348
[8]. Bhaskar V.H., Mohite P.B., Pandhare R.B. Acta Pharm. Sci., 2010, 52:504
[9]. Mamdouh A.S., Samy B.S., Said H.K. Der Pharma Chemica, 2012, 4:1064
[10]. Shukla S., Srivastava R.S., Shrivastava S.K., Sodhi A.P.K. Med Chem Res., 2013, 22:1604
[11]. AL-Rawi M.S., Hassan H.A., Hassan D.F., Orient. J. Chem., 2018, 34:2826
[12]. Hutham M.Y., Al-Labban, Research J. Pharm. and Tech., 2017, 10:3645
[13]. Muna S., Al-Rawi, Hussei A.F., Al-Taie M.M., Al-Halbosiy, Hameed B.A. IOP Conf. Series: Journal of Physics:Conf. Series., 2018, 1003:012012
[14]. Sliverstien R.M., Websters X., John Wiely and Sons. New York., 1998
[15]. Suaad M.H., Lawand H.K. Journal of Zankoi Sulaimani, 2015, 17:49
[16]. Basheer H.A., Ibrahim A.A., Ahmed M.S. Swift J. Pure Appl. Chem., 2018, 2:4