TY - JOUR ID - 109230 TI - A greener and sustainable approach towards the synthesis of propargylamine using multicomponent A3-coupling reaction JO - Asian Journal of Green Chemistry JA - AJGC LA - en SN - 2588-5839 AU - Singha, Rabindranath AU - Brahman, Dhiraj AU - Sinha, Biswajit AU - Ghosh, Pranab AD - Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India Y1 - 2021 PY - 2021 VL - 5 IS - 1 SP - 91 EP - 110 KW - Organo-copper complex KW - C-C coupling reaction KW - Multicomponent KW - Heterogeneous catalyst DO - 10.22034/ajgc.2021.109230 N2 - The abundance of toxic contaminated effluents from the pharmaceutical industries and the serious risk of contamination of the aquatic systems combine to provide strong motivating factors to tackle this environmental problem. Use of non hazardous chemicals, reaction in aqueous medium is an interesting ecological alternative for the bulk production of important drugs and fine chemicals. Taking advantage of the remarkable ability of the selected catalytic systems, alternative sustainable methods have been exploited for the decontamination of industrial effluents and exhausts. Working in the same direction herein, we present a newly developed metal-organic complex [Bis(picolinate-κ2N:O) Cu(II)] catalysed A3-coupling reaction in water which has established an excellent greener protocol to yield propargylamine. Low toxicity, easy access to active sites, high surface area, high thermal stability, recyclability of the catalyst and easy way to separate the catalyst from the reaction mixture are the added advantage of this developed greener and sustainable protocol. UR - https://www.ajgreenchem.com/article_109230.html L1 - https://www.ajgreenchem.com/article_109230_1387208512384a5b2ff91fce127221ec.pdf ER -