@article { author = {Mohammadi Zeydi, Masoud and Mahmoodi, Nosrat O Allah and Ardeshiri Terogeni, Ghorban}, title = {Sulfonylbis(1,4-phenylene)bissulfamic acid (SPSA): Introduction of an efficient and reusable catalyst for the synthesis of bis(indolyl)methanes}, journal = {Asian Journal of Green Chemistry}, volume = {1}, number = {2}, pages = {78-88}, year = {2017}, publisher = {Sami Publishing Company}, issn = {2588-5839}, eissn = {2588-4328}, doi = {10.22631/ajgc.2017.95432.1013}, abstract = {A simple, efficient and convenient route is described for the synthesis of bis-indolyl methanes by using recyclable catalyst sulfonylbis(1,4phenylene)bissulfamic acid (SPSA). In this procedure, we synthesize a bis-indolyl methane derivative via the three component reactions of two equivalent indoles with one equivalent of various aromatic aldehydes in the presence of 10 mol% SBSA as a heterogeneous catalyst under solvent-free conditions at 110 °C for the convinced reaction times (30–60 min). The advantages of this protocol towards the synthesis of bis-indolyl methane derivatives are: I) use of solvent-free conditions, II) inexpensive catalyst, III) using commercially available precursors, d) reusability of SBSA up to several cycles without much loss in reactivity, IV) simple work-up, V) high yields of pure products, VI) short reaction times. The structure of all bis(indolyl)methane derivatives were confirmed by melting point, FT-IR, 1H NMR spectra and were compared with reliable references. }, keywords = {Sulfonylbis(1,4-phenylene)bissulfamic acid (SPSA) Bis-indolyl methanes Aldehyde Indoles Multi-component reactions}, url = {https://www.ajgreenchem.com/article_49782.html}, eprint = {https://www.ajgreenchem.com/article_49782_4ccd4074ddc8d367d502133bdc7d2078.pdf} }