Fatemeh Hakimi Saryazdi; Elham Golrasan; Somaya Heidari
Abstract
In this work, a green and effective method for the synthesis of pyrazole derivatives by the reaction of a pot of various 1,3-dicarbonyl compounds with hydrazine is proposed using graphene ...
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In this work, a green and effective method for the synthesis of pyrazole derivatives by the reaction of a pot of various 1,3-dicarbonyl compounds with hydrazine is proposed using graphene oxide nanoparticles as the Lewis base catalyst. Advantages this methods are high yields, perform quick reactions, easy customization, and short-term reaction. The catalyst was recycled several times. The recycled catalyst was reused without any apparent performance drop in subsequent reactions. This process provided not only self-condensation but also cross-condensation by using the hydra-friendly nuclear reaction of hydrazines and high-efficiency, multisubstituted pyrazoles were formed under good and easy conditions.
