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Document Type : Original Research Article


Faculty of Chemistry, Urmia University, 5756151818, Urmia, Iran


A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.

Graphical Abstract

One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives


Main Subjects

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