%0 Journal Article %T Organocatalytic enantioselective one-pot synthesis of β-aminoketones via Mannich reaction %J Asian Journal of Green Chemistry %I Sami Publishing Company %Z 2588-5839 %A Menkudle, Madhavi S. %A Chakrawar, Avinash V. %A Kulkarni, Prashant M. %A Jadhav, Wamanrao N. %A Bhusare, Sudhakar R. %D 2020 %\ 07/01/2020 %V 4 %N 3 %P 249-255 %! Organocatalytic enantioselective one-pot synthesis of β-aminoketones via Mannich reaction %K Mannich reaction %K Organocatalyst %K β-amino carbonyl compounds Enantioselectivity %K Multicomponent reaction %R 10.22034/AJGC/2020.3.2 %X An effective protocol for the asymmetric synthesis of β-amino carbonyl compounds using pyrrolidine based organocatalyst has been developed via one-pot three-component Mannich reaction. The organocatalyst (S)-N-(2,4-dinitrophenyl) pyrrolidine-2-carboxamide 3b confirmed to be the superior organocatalyst in solvent acetonitrile to obtain corresponding products in up to 89% yield and with excellent ee (90%). This organocatalytic reaction reveals productive result with a range of other aldehydes. Aromatic aldehydes having electron withdrawing substituent show the best results. Excellent yields, high enantioselectivity, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method. %U https://www.ajgreenchem.com/article_92796_e0529311505ddbadadb67b0149db1595.pdf