%0 Journal Article %T One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives %J Asian Journal of Green Chemistry %I Sami Publishing Company %Z 2588-5839 %A Javahershenas, Ramin %A Khalafy, Jabbar %D 2018 %\ 10/01/2018 %V 2 %N 4 %P 318-329 %! One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives %K β-Aminocrotonitrile Arylglyoxal 1 %K 3-Dimethylbarbituric acid Thiobarbituric acid TEA (triethylamine) %R 10.22034/ajgc.2018.62714 %X A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities. %U https://www.ajgreenchem.com/article_62714_d3a41b77a962a33d9085f09b7faaebb6.pdf